Acute coagulopathy of trauma: Mechanism, monitoring, management
نویسندگان
چکیده
منابع مشابه
Acute Traumatic Coagulopathy: an Endogenous Precursor of Trauma-induced Coagulopathy
Recent findings Trauma causes an acute disruption of the equilibrium between all components of haemostasis (coagulation, anticoagulation, fibrinolysis, platelets and endothelium). In patients with a combination of severe tissue damage and systemic hypoperfusion, this will progress rapidly to an endogenous coagulopathy that is independently associated with worse outcomes. New discoveries of the ...
متن کاملAcute coagulopathy of trauma in the rat.
INTRODUCTION Acute coagulopathy of trauma (aCOT) is a state of disordered coagulation developing soon after severe injury and blood loss and has been defined in the clinical literature as an elevation in prothrombin time (PT) and activated partial thromboplastin time (aPTT). OBJECTIVE The purpose of this study was to develop a rat model of aCOT resulting from polytrauma and hemorrhage and sho...
متن کاملAcute traumatic coagulopathy and trauma-induced coagulopathy: an overview
Hemorrhage is the most important contributing factor of acute-phase mortality in trauma patients. Previously, traumatologists and investigators identified iatrogenic and resuscitation-associated causes of coagulopathic bleeding after traumatic injury, including hypothermia, metabolic acidosis, and dilutional coagulopathy that were recognized as primary drivers of bleeding after trauma. However,...
متن کاملProgresses in understanding trauma-induced coagulopathy and the underlying mechanism
Trauma-induced coagulopathy (TIC) is a clinical syndrome caused by imbalance between clotting, anti-coagulation and fibrinolysis resulting from multiple pathological factors such as hemorrhage and tissue injury in the early stage of trauma, and is closely related to the outcome of trauma patients. It is proved in growing evidence that the endogenous coagulation disturbance in trauma itself is t...
متن کاملAcute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis.
BACKGROUND Coagulopathy is present at admission in 25% of trauma patients, is associated with shock and a 5-fold increase in mortality. The coagulopathy has recently been associated with systemic activation of the protein C pathway. This study was designed to characterize the thrombotic, coagulant and fibrinolytic derangements of trauma-induced shock. METHODS This was a prospective cohort stu...
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ژورنال
عنوان ژورنال: World Journal of Anesthesiology
سال: 2014
ISSN: 2218-6182
DOI: 10.5313/wja.v3.i1.111